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Myeloproliferative Neoplasm (MPN) and the MAGIC risk assessment tools

MAGIC, the MPN Assessment Graphic Internet Calculator,  is a convenient and graphic means to summarize broad clinical experience in assessing overall risk-associated condition for myelofibrosis, polycythemia vera and essential thrombocythemia.

For Myelofibrosis

MAGIC relies on two commonly used and validated scales developed by the International Working Group on Myeloproliferative Neoplasms Research and Treatment (IWG-MRT). Together, the DIPSS (Dynamic International Prognostic Scoring System) and the DIPSS + assess the degree of myelofibrosis risk.*

There are four MF Risk Levels (Low, Intermediate-1, Intermed-2, and High) Each Risk Level carries a mean approximation of overall survival (OS) expressed in years and months. The OS is only a guideline.   Mean survival is the midpoint between the number of those who will live longer and those who will die earlier.”

Myelofibrosis is a complex and still largely unexplored disease whose etiology and progression is only partially understood. Beyond the clinical elements measured by our scales, some factors influencing survival include genetics, environment, co-morbidities, diet, lifestyle, epigenetics, geography, occupation, and , emotional, social and psychological elements.

The MAGIC results are significant , however, in revealing a patient’s underlying general risk status and can serve as a guide to undertake minimal or more aggressive therapies.