Green Risk Level


Congratulations. Your LOW RISK score means you have time to prepare for a possible stem cell transplant in the future.  Talk to your hematologist about finding a qualified stem cell donor and investigate transplant centers

According to one DIPSS+ study2 median LOW RISK survival for MF patients is estimated to be about 15 years. This figure implies that half the patients will live at least fifteen years. Other prognostic scales2 using additional risk factors estimate much shorter survival times for higher levels of risk.

Because of great differences among patients, survival figures are only approximate. A patient’s condition, genetic predisposition, and co-morbidities are just some of the factors that play a role in longevity. It is important to review your Risk Level with your hematologist both for accuracy and for inclusion of additional factors that might impact your therapeutic options.  Some of those factors are fibrosis grade, swollen spleen, transfusion dependence, high risk mutations, and defective chromosomes.

What is known for certain is that qualified patients who start stem cell transplant in good condition and early enough in the MF disease process have far better outcomes than patients who wait until the onset of end-stage symptoms.3

See Notes on MPN mutations for details on your individual mutations

    1. Passamonti, Blood, 2010 115:1703-1708
    2. Gangat et al., J Clin Oncol. 2011, February
    3. Scott, et al., Blood, 2012 Mar 15; 119 (110): 2657-2664)